Tuscany Road Trip: 6-Day Itinerary

Florence, the beautiful capital of the Italian region Tuscany, lies in the center of the country. A small city with a big heart, and an even bigger offering of artistic and historical treasures. For centuries, travelers have journeyed to the birthplace of the Renaissance era to marvel at the many masterpieces of architecture and art: Michelangelo's iconic David, the impressive works of Botticelli, the Uffizi Gallery (packed with works by Caravaggio and Da Vinci), and of course, Brunelleschi's remarkable dome — the religious centerpiece of Florence that dominates the skyline. All are absolute must-sees on any itinerary. Once you've ticked off these renowned attractions, you can take a stroll through the vast Boboli Gardens or climb the hill to the church of San Miniato al Monte for a breathtaking view of this beautiful, enchanting city.

Spread across three hills in the heart of Tuscany, the compact city of Siena is a historic gem centered around the sloping Piazza del Campo. Overlooked by the magnificent Palazzo Pubblico, the city is known worldwide for the famous Palio, a horse race held around the piazza twice every summer. Siena has remarkably preserved its quaint old-world charm. Its stunning Gothic buildings include the city’s Duomo, which is arguably one of Italy’s most impressive Gothic cathedrals, along with numerous other architectural treasures. The city also boasts a wealth of exceptional early Renaissance art. Meanwhile, Siena buzzes with modern life, and each of its 17 neighborhoods is uniquely captivating.